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Stay in the Sun Six Times Longer with a Base Tan

Published on May 22, 2013

Joint Canadian Tanning Association recommends indoor tanning to build a base tan before outdoor vacations this summer. A base tan can give you up to six times the protection from sunburning in the natural sun.

When tanning indoors or outdoors be Responsible. Everything in Moderation!

Base Tans Work

Kelowna, BC (PRWEB) April 10, 2013

After several long months of frigid cold and snow, many Canadians anxious to put the winter behind them have already begun planning their summer escapes in the sun.

Beach getaways, cottage vacations and carefree weekends on the golf course are just around the corner for thousands who have been counting down the days on their calendars.

But too much sun without a proper base tan can quickly take the fun out of summer holidays, says the Joint Canadian Tanning Association (JCTA).

The association says those planning to enjoy the outdoors this summer should first protect themselves by going indoors to professional tanning salons to develop a natural base tan through responsible exposure to Ultra Violet light.

“Building a gradual base tan in a controlled environment provided by our member salons can increase natural protection against potentially harmful sunburn by up to six times,” says JCTA Executive Director Steven Gilroy “A base tan adds a foundational layer of sunburn protection, increasing the effectiveness of sunscreens applied to the skin.”

Developing a base tan prior to sun vacations through UV exposure at indoor tanning salons protects against sunburn by increasing production of melanin pigment and thickening of the outer skin , which shield the skin and enable it to withstand increased sun exposure.

Trained and industry certified operators at a JCTA professional tanning salons develop tanning schedules for clients to ensure they are able to build base tans gradually and responsibly. Typically, it takes a minimum of 10 tanning sessions over at least three to six weeks to develop an effective base tan, the JCTA says.

“The greatest thing about a good base tan is that it’s all-natural protection, unlike chemical sunscreens that can contain ingredients which have been found to be harmful,” Gilroy says. “An added advantage is that base tans don’t wear off like sunscreens, if you go swimming or sweat in the heat.”

Even with the added protection of a suitable base tan, the JCTA warns sun lovers who want to stay outdoors for lengthy periods to avoid overexposure to sun light by seeking shade, covering up with light clothing, using safe sunscreens and applying sunscreens correctly.

Please Tan Responsibly and know your Skin Type

 
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Sunlight could help to lower blood pressure

Published on May 9, 2013

Spending 20 minutes in the sun could help to lower your risk of heart disease, scientists have claimed.

Researchers at the University of Edinburgh found that exposure to ultraviolet light lowered the blood pressure of volunteers.

Scientists say the findings may lead them to reconsider current advice for sun exposure.

High blood pressure is one of the main risk factors in heart disease and stroke. Around a third of the population suffer from high blood pressure.

The scientists believe that UV rays in sunlight cause nitrogen stored in the body to be released into the blood stream, relaxing blood vessels and lowering blood pressure.

However, excessive exposure to UV light is also known to be a major cause of skin cancer, so experts have warned the public against spendnig too much time in the sun unprotected.

Dr Richard Weller, a senior lecturer in dermatology at the University of Edinburgh who led the research, cautioned that more work needs to be done before they were able to offer advice to patients about using sunlight as a treatment for high blood pressure.

He said: “We now plan to look at the relative risks of heart disease and skin cancer in people who have received different amounts of sun exposure.

“If this confirms that sunlight reduces the death rate from all causes, we will need to reconsider our advice on sun exposure.

“We suspect that the benefits to heart health of sunlight will outweigh the risk of skin cancer.”

The researchers, who are presenting their findings at the International Investigative Dermatology Conference in Edinburgh, studied the blood pressure of 24 volunteers.

They were asked to spend 20 minutes under a UV tanning lamp, which allowed the dose of light to be controlled.

The scientists found while after receiving UV light, the volunteers’ blood pressure dropped and remained lower than before exposure for up to an hour.

When the volunteers were exposed to heat but no UV light from the tanning lamps, their blood pressure also dropped during exposure but then quickly increased back to previous levels.

Laboratory tests also showed that skin cells exposed to UV light released nitric oxide, a nitrogen based chemical that is known to cause blood vessels to relax.

UV from sunlight is known to have a number of benefits by helping the body produce vitamin D, but it is also the main cause of damage that causes skin cancer.

Nina Goad, from the British Association of Dermatologists, warned that the latest findings were still in their early stages as the study had been very small.

She said: “Research in this area is still very much in its infancy.

“Emerging evidence about possible health benefits of sunlight do not invalidate the indisputable weight of evidence showing the link between excess UV exposure and skin cancer, which is the UK’s most common form of cancer.”

Dr Clare Walton, research communications officer at the Stroke Association, added: “We know that moderate exposure to sunshine can have multiple health benefits, however this is the first time that the link between sunshine and stroke risk has been explored.

The results show that sun exposure can reduce blood pressure, which is the biggest risk factor for stroke. It will be interesting to see how long these positive effects last and whether sunshine can play a role in reducing stroke risk.

“However, it’s an extremely small study and a lot more research is needed. It’s also important to remember that exposure to excess sunshine can be harmful to our health and everyone should take the necessary precautions this summer.”

 
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Top 10 Super Foods – Presented by Beauty Research

Published on May 3, 2013

We’ve all heard the buzz about super foods, those superheroes of nutrition that save your body from obesity and disease while raising your energy levels. Food manufacturers and restaurants have caught onto the craze and seem to bill everything from muffins to sports drinks as “super.” Curious about which foods truly lived up to the title; I conducted some research of my own and then created this top 10 list of super foods.

1. Salmon - Whether you like it grilled, broiled or raw as sushi, salmon is one of the best sources of omega fatty acids around. Eat just 3 ounces of the fish, and you’ll have consumed 100 percent of your body’s daily requirements for omega 3. Studies have found that omega 3 helps with brain function, improves cardiovascular health and can keep joints healthy and strong. Just make sure to opt for wild-caught salmon, which is lower in calories and richer in nutrients than farmed.

2. Organic Tea - Organic red, green and black teas are very rich in antioxidants, nutrients that fight the free radicals that cause our bodies to age. In clinical studies, green tea has been found to lower one’s risk of developing cancer, slash cholesterol levels and even improve hardening of the arteries in men with heart disease.

3. Acai - Another excellent partner in the fight against free radicals, the acai berry contains more than 10 times the amount of antioxidants found in grapes. Acai berries are also high in dietary fiber and contain all of the amino acids that your body requires. If you choose to drink acai berry juice, be sure to look for 100 percent pure juice rather than drinks with acai berry flavoring.

4. Hot Peppers - Capsaicinoids, the chemicals in hot peppers that make them so intense on the palate, are remarkably good for the body. These natural chemicals fight inflammation and are shown to alleviate symptoms of arthritis, increase the metabolism and lower the risk of cancer. Chili peppers contain double the amount of Vitamin C found in oranges, making them excellent for boosting the immune system.

5. Quinoa - Sometimes lumped in with grains, quinoa is actually a seed that is very rich in amino acids, fiber and protein. In clinical studies, quinoa has been shown to improve blood pressure, cholesterol and blood sugar levels. Quinoa is easy to add to the diet because it can be used as a substitution for rice and almost all types of grains.

6. Seeds - Nearly all seeds provide massive doses of key nutrients that are highly beneficial for the body. For example, flaxseed is the best dietary source for cancer-fighting lignans, and just one-quarter cup of sunflower seeds gives you half of your day’s vitamin E requirements. When purchasing roasted seeds, be sure to check sodium levels or purchase raw seeds to add to recipes or roast on your own.

7. Yogurt - Calcium is absolutely essential to bone health and is particularly important for women as we age. One serving of yogurt has more calcium than a single serving of whole milk or cheese. In fact, the only natural food with more calcium per serving than yogurt is sardines. When choosing yogurts, opt for Greek varieties, as these tend to contain double the lean protein found in traditional yogurt.

8. Spinach and other Leafy Greens - Turns out Popeye really was strong because of his spinach. This green contains 500 percent of one day’s dose of vitamin K, which is essential to bone health and helps with blood clotting. Other leafy greens are also excellent sources for key nutrients, such as collard greens, which contain vitamin A and nutrients that are essential for eyesight. Mustard greens, kale and watercress are additional nutritious greens. It’s best to consume your greens raw…such as, in salads, smoothies and sauces in order to get the full benefits of their nutrients.

9. Garlic - Flavonoids in garlic encourage the body to produce the antioxidant glutathione, which is vital to fighting disease and promoting cardiovascular health. Garlic is known to lower the risk of some forms of cancer, decrease blood pressure and cholesterol levels, boost brain functioning in Alzheimer’s patients and help the immune system fight illnesses.

10. Avocados - Every healthy diet must include some fats, and you won’t find a healthier source than avocados. Studies have found that avocados help the body to absorb key nutrients, particularly when consumed simultaneously with a wholesome food, such as in a salad, sauce or on a sandwich.

I hope this list will help you make better decisions at mealtimes and incorporate more wholesome, nutritious foods into your diet. While you simply can’t eat all of these super foods every day, make it a goal to eat at least one or two daily. For specific dietary advice about how many super foods your body requires, talk to your doctor or see a nutritionist.

 
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Low Vitamin D Tied to Fibroids

Published on April 29, 2013

Inadequate levels of vitamin D may increase the risk for uterine fibroids, a new study reports.

Vitamin D has been associated with reduced risk for various diseases, but this is the first to examine the connection to fibroids, benign tumors of the uterus that can cause pain and bleeding.

Researchers randomly selected 620 black and 410 white women, ages 35 to 49, and determined their vitamin D levels with blood tests and their health status with questionnaires. Their analysis appears in the May issue of Epidemiology.

About two-thirds of the women had fibroid tumors. In the entire group, only 10 percent of the black women and 50 percent of white women had vitamin D levels above 20 nanograms per milliliter, generally considered an adequate level.

After adjusting for age, physical activity, sun exposure and other variables, they found that having a vitamin D level above 20 decreased the risk for fibroids by 32 percent, and that each increase of 10 nanograms per milliliter in vitamin D was associated with a 20 percent lower risk of having a fibroid tumor.

The lead author, Donna Day Baird, an epidemiologist with the National Institutes of Health, cautioned that this was only one epidemiological study and needed to be replicated. Still, she said, “sufficient levels of vitamin D are probably good for several health outcomes, and fibroids may be one of them.”

 

By NICHOLAS BAKALAR

 
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Airbrush Video by Norvell

Published on April 24, 2013

 
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Moisturizers: Options for softer skin

Published on April 17, 2013

Find out what moisturizers can and can’t do for your skin and how to select a moisturizer that suits your needs.

By Mayo Clinic staff

Moisturizers prevent and treat dry skin, but that’s not all they do. Moisturizers can protect sensitive skin, improve skin tone and texture, and mask imperfections. There are plenty of different moisturizers available. Here’s help finding the right moisturizer for you.

Which moisturizer is best for you?

On the most basic level, moisturizers hold water in the outermost layer of skin. They also act as a temporary barrier. Many moisturizers contain some combination of humectants and emollients, as well as other ingredients.

The moisturizer that’s best for you depends on many factors, including your skin type, your age and whether you have specific conditions, such as acne. For general guidelines, consider the following:

  • Normal skin. Normal skin is neither too dry nor too oily. To maintain this natural moisture balance, use a water-based moisturizer that has a light, nongreasy feel. These moisturizers often contain lightweight oils, such as cetyl alcohol, or silicone-derived ingredients, such as cyclomethicone.
  • Dry skin. To restore moisture to dry skin, choose a heavier, oil-based moisturizer that contains ingredients such as antioxidants, grape seed oil or dimethicone, which helps keep your skin hydrated. For very dry, cracked skin, petrolatum-based products are preferable. They have more staying power than creams do and are more effective at preventing water from evaporating from your skin.
  • Oily skin. Oily skin is prone to acne and breakouts. Though oily, such skin still needs moisture, especially after using skin care products that remove oils and dry out the skin. A light moisturizer can also help protect your skin after washing. Choose a water-based product that’s labeled “noncomedogenic,” which means it won’t clog pores.
  • Sensitive skin. Sensitive skin is susceptible to skin irritations, redness, itching or rashes. Look for a moisturizer that contains soothing ingredients such as chamomile or aloe and doesn’t contain potential allergens, such as fragrances or dyes. Also, avoid products containing acids, which can irritate sensitive skin.
  • Mature skin. As you age, your skin tends to become drier because your oil-producing glands become less active. To keep your skin soft and well hydrated, choose an oil-based moisturizer that contains petrolatum as the base, along with antioxidants or alpha hydroxy acids to combat wrinkles. These ingredients help hold in moisture and prevent flaky, scaly skin.

Getting the most out of your moisturizer

To make the most of your moisturizing routine:

  • Be willing to experiment. Find a moisturizer that fits your skin type and makes your skin look and feel soft. You may need to try several brands with varying ingredients before you find one you like.
  • Protect yourself from the sun. Choose a moisturizer that contains sunscreen, which performs double duty by hydrating your skin and protecting it from sun damage.
  • Don’t necessarily buy the most expensive brand. Keep in mind that cost has no definite relationship to effectiveness. Just because a moisturizer is expensive doesn’t mean it’s more effective than a cheaper product.
  • Apply moisturizers immediately after bathing. Pat or blot your skin until it’s just barely dry, then apply moisturizer immediately to help trap water in the surface cells.
  • Apply moisturizer to your hands and body as needed. Apply after bathing or showering, before exercising outdoors in cold weather, and every time you wash your hands. Although often ignored, your hands are more exposed to the elements, especially soaps and chemicals, than is any other part of your body.
  • Use heavy creams appropriately. Don’t use any heavy creams on your face unless you have excessive dryness. You can use heavy, oil-based creams on your legs, hands and feet because those areas tend to be drier.

Keep in mind that there’s no guarantee that any moisturizer will live up to all of its claims or even contain its advertised ingredients. Moisturizers are considered cosmetics, so the Food and Drug Administration (FDA) regulates them in a different and more lenient manner than it does drugs. This means that products don’t need to undergo the same rigorous testing for safety and effectiveness before going to market that prescription drugs do.

If a moisturizer doesn’t improve the condition of your skin or you notice skin problems after using a moisturizer, see your doctor or dermatologist. He or she can help you create a personalized skin care plan by assessing your skin type, evaluating your skin’s condition and recommending moisturizers likely to be effective.

 
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Summer Skin Care Guide for Men

Published on April 12, 2013

Most men still believe that skin-care regimen and changing products according to the weather are in a women’s to-do list. But you can’t be more wrong!

Men typically have larger pores on their skin so they are more prone to break-outs and clogged pores. They do not use any type of translucent powder like women do to absorb excess oil. They also spend more time out in the humid temperatures of summer, and hence are likely to have a problematic skin. So how will you take care of your skin to maintain a healthy glow? Don’t sweat it – just a few changes are all it takes to have an effective summer skin care routine. Read on…

1) Cleanse Your Face Twice A Day

Men’s skin is oilier to begin with. So, cleaning the face twice a day, with a good quality cleanser or face wash and not scrubbing it with soap is imperative. It cleans the pores and removes excess oil. Clarifying cleansers form a very important part of a man’s daily skin care routine. It reaches deep inside the pores and prepare it for shave or exfoliation. Cleansers which contain Vitamins A, C and E are absorbed more into the skin; they prevent ingrown hairs and keep the skin naturally healthy.

2) Use A Toner

Men’s skin is tougher and thicker than a woman’s skin. It can tolerate active ingredients in toners like astringent or Glycolic acid (GA). GA helps in keeping the pores clean throughout the day, restores the balance of the skin and reduces the risk of ingrown hairs after shaving.

3) Exfoliate

Getting rid of the dead skin cells via natural scrubbing is also important during summers. Men should typically go for deep exfoliation once in every 3 days or visit a men’s salon once a week for professional exfoliation. Natural glow can only be attained if you remove the older dead cells and nourish the younger skin cells.

4) Moisturize

Use a lightweight moisturiser with SPF 15 or above. It will help keep your skin moisturised, wrinkle-free, prevent any fine lines to appear on the face and will restore the moisture balance after exfoliation. It will also heal your skin, especially if you have been under the sun too long.

5) Don’t Over-Shave

Try to avoid shaving everyday in summers. You skin works overtime during this weather as it repairs and heals after every shave, battle out the UV rays of sun and generates and de-generates as it has its own repair mechanism.

6) Use An Aftershave

It helps to restore lost moisture and oils after a close shave. You’ll also need an aftershave to protect your skin and reducing the sensitivity to the sun. Look out for a natural aftershave and nourishing oils for an even toned complexion.

7) Wear Sunscreen Everyday

This goes without saying but a sunscreen will work if you use it in a correct way. Be sure to use a sun block 30 minutes before heading outdoors. Apply a sunscreen after every 2 hours regardless of the SPF because it wears off on its own, by touching, using a towel, sweating and washing your face. Apply it on all parts of your body. Don’t forget your ears, hands and feet. Use a lip balm with sun protection to guard your lips.

8) Banish Body Odor

Using deodorant is not the only solution for getting rid of the body odor. Odour arises only when bacteria mixes with your sweat, so start from the basic level. Use an anti-bacterial cleanser or body wash while showering. After which apply a herbal powder and use a deodorant later once you are dressed up.

9) Eat Healthy

Our skin is hugely impacted by our diet and lifestyle choices. Tomatoes, avocados, berries, almonds and apricots should be included in your diet as these food items have anti-aging properties. They also act as anti-oxidants which protects your skin from wrinkles thereby keeping it naturally healthy. Needless to say, drink a lot of water and flush out impurities from your body. Avoid oily and deep fried food as the process of digestion slows down during summer and oily foods are hard to digest. Include more leafy vegetables, pulses, yogurt, salmon and chicken in your regular diet for a glowing skin.

10) If You Have Acne

Acne products which have salicylic acid can dry out your skin and make it more prone to sunburn. These products can rip off the top layer of your skin thereby making it more sensitive to UV rays. Use these products only at night and consult your dermatologist before using a moisturiser.

So you see, a complicated skin care routine isn’t required for a clean and healthy looking skin. You don’t have to invest in a slew of products or spend hours in a beauty care salon. Just a few adjustments in your daily life and you’re good to go!

 
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Study Reveals Potential Immune Benefits of Vitamin D Supplements in Healthy Individuals

Published on March 24, 2013

Research from Boston University School of Medicine (BUSM) shows that improving vitamin D status by increasing its level in the blood could have a number of non-skeletal health benefits. The study, published online in PLOS ONE, reveals for the first time that improvement in the vitamin D status of healthy adults significantly impacts genes involved with a number of biologic pathways associated with cancer, cardiovascular disease (CVD), infectious diseases and autoimmune diseases. While previous studies have shown that vitamin D deficiency is associated with an increased risk for the aforementioned diseases, these results go a step further and provide direct evidence that improvement in vitamin D status plays a large role in improving immunity and lowering the risk for many diseases.

Vitamin D is unique in that it can be both ingested and synthesized by the body with sun exposure. It is then converted by both the liver and kidneys to a form that the body can use. An individuals’ level of vitamin D, or their vitamin D status, is determined by measuring the level of 25-hydroxyvitamin D in the blood. Vitamin D deficiency, which is defined as a status of less than 20 nanograms per milliliter (ng/mL) of 25-hydroxyvitamin D, can cause a number of health issues, including rickets and other musculoskeletal diseases. Recently, however, data suggests that vitamin D deficiency (<20 ng/mL) and vitamin D insufficiency (between 21-29 ng/mL) is linked to cancer, autoimmune diseases, infectious diseases, type 2 diabetes and cardiovascular disease.

The randomized, double-blind, single-site pilot trial involved eight healthy men and women with an average age of 27 who were vitamin D deficient or insufficient at the start of the trial. Three participants received 400 International Units (IUs) of vitamin D per day and five received 2,000 IUs per day for a two-month period. Samples of white blood cells (immune cells) were collected at the beginning of the two-month period and again at the end. A broad gene expression analysis was conducted on these samples and more than 22,500 genes were investigated to see if their activity increased or decreased as a result of the vitamin D intake.

At the end of the pilot, the group that received 2000 IUs achieved a vitamin D status of 34 ng/mL, which is considered sufficient, while the group that received 400 IUs achieved an insufficient status of 25 ng/mL.

The results of the gene expression analysis indicated statistically significant alterations in the activity of 291 genes. Further analysis showed that the biologic functions associated with the 291 genes are related to 160 biologic pathways linked to cancer, autoimmune diseases, infectious diseases and CVD. Examining gene response elements, or sequences of DNA bases that interact with vitamin D receptors to regulate gene expression, they also identified new genes related to vitamin D status. To ensure that their observations were accurate, the researchers looked at 12 genes whose level of expression does not change, and those genes remained stable throughout the trial period.

“This study reveals the molecular fingerprints that help explain the non-skeletal health benefits of vitamin D,” said Michael F. Holick, PhD, MD, professor of medicine, physiology and biophysics at BUSM and leading vitamin D expert who served as the study’s corresponding author. “While a larger study is necessary to confirm our observations, the data demonstrates that improving vitamin D status can have a dramatic effect on gene expression in our immune cells and may help explain the role of vitamin D in reducing the risk for CVD, cancer and other diseases.”

This research was supported by a pilot grant from the National Institutes of Health’s Clinical Translational Science Institute under grant award # UL-1-RR-25711.

 
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How to maintain an airbrush tan

Published on March 19, 2013

Do not shower, work out or make contact with water for at least 8 hours after a tan. For a longer lasting, darker tan we recommend waiting 10 to 12 hours to shower. Avoid using Dove or Dial products to maintain your tan. It is best to use mild, moisturizing liquid soaps when showering. Use shaving cream or hair conditioner when shaving. Avoid exfoliates such as salt, sugar, or beaded scrubs at all costs. Exfoliating will only speed up the fading process.

The most important thing you can do to maintain your tan is to MOISTURIZE! The dryer your skin is the quicker it will fade. Best time to moisturize is after your shower. As well, avoid staying in chlorinated pools for long periods of time and after showering or working out don’t rub your skin dry, just pat or air dry. And again most importantly… MOISTURIZE! MOISTURIZE! MOISTURIZE! Check out some of our amazing moisturizes which will add some extra color and elongate the life of your tan.

Airbrush tanning lasts about seven to 10 days. As the skin naturally exfoliates, the tan is lost. Keeping the skin hydrated will help to keep the tan as long as possible. Exfoliating before airbrush tanning may help to maintain a longer tan. It is recommended for those who use airbrush tanning to avoid using any type of abrasive, exfoliating products after the tanning solution is applied, though use of moisturizers is encouraged.

 
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Guardian of the genome protein found to underlie skin tanning

Published on March 13, 2013

A protein known as the “master watchman of the genome” for its ability to guard against cancer-causing DNA damage has been found to provide an entirely different level of cancer protection: By prompting the skin to tan in response to ultraviolet light from the sun, it deters the development of melanoma skin cancer, the fastest-increasing form of cancer in the world.

In a study in the March 9 issue of the journal Cell, researchers at Dana-Farber Cancer Institute report that the protein, p53, is not only linked to skin tanning, but also may play a role in people’s seemingly universal desire to be in the sun — an activity that, by promoting tanning, can reduce one’s risk of melanoma.

“The number one risk factor for melanoma is an inability to tan; people who tan easily or have dark pigmentation are far less likely to develop the disease,” says the study’s senior author, David E. Fisher, MD, PhD, director of the Melanoma Program at Dana-Farber and a professor in pediatrics at Children’s Hospital Boston. “This study suggests that p53, one of the best-known tumor-suppressor proteins in our body, has a powerful role in protecting us against sun damage in the skin.”

In a study published last year, Fisher and his colleagues found that ultraviolet (UV) radiation from the sun causes skin cells called keratinocytes to make and secrete a hormone called α-MSH, which attaches to nearby skin cells called melanocytes and spurs them to produce skin-darkening pigment called melanin. The chain of events within keratinocytes that leads to α-MSH production, however, was a mystery.

Investigators knew that α-MSH is created when another protein, known as pro-opiomelanocortin (or POMC), is split apart. They also knew that the amount of POMC within cells rises sharply when they’re exposed to UV rays. But they didn’t know what caused the POMC to increase.

One possibility was p53. When Fisher and his colleagues examined the section of the gene for POMC that promotes production of the protein, they found it meshed nicely with p53 — suggesting that when p53 docks there, it revs up POMC production. Additional evidence came when the researchers exposed human and mouse keratinocytes to UV radiation: After six hours, levels of both POMC and p53 were far higher than normal, and the level of pigment-stimulating α-MSH was 30 times above normal.

Further experiments clinched the case for p53′s role in tanning. When researchers inserted p53 into keratinocytes, POMC levels rose dramatically. When they delivered UV radiation to mice whose keratinocytes lacked p53, POMC production was not induced and the mice did not tan.

The implications of the research go beyond tanning. A common skin condition, especially among the elderly, is the development of small, dark spots that are unrelated to sun exposure. The spots arise when groups of cells begin producing pigment in response to repeated stress or irritation of the skin. Although not dangerous, the condition can be a cosmetic problem, depending on its location.

“Our research offers a potential explanation of how this condition — known as post-inflammatory hyperpigmentation, or age spots — occurs,” Fisher says. “We know that it occurs as a result of stress, and p53 is a classic ‘stress’ protein, going into action when cells experience stress-related DNA damage. What we’ve learned about p53 suggests that it may trigger the hyperpigmentation process.”

There is even the possibility that p53 protects against skin damage in a second — and previously unsuspected — way. The protein not only causes skin to tan in response to sunlight, it may also underlie people’s desire to spend time in the sun.

The same process that causes POMC to produce α-MSH also leads to the production of β-endorphin, a protein that binds to the body’s opiate receptors and may be associated with feelings of pleasure. “Even as p53 is causing skin to tan during sunlight exposure, it may also affect neuronal circuits,” Fisher says. “These proteins may provide an explicit link between the regulation of tanning and of mood. It raises the question of whether p53-mediated induction of β-endorphin is involved in sun-seeking behavior, which often increases skin cancer risk.”

The study’s lead author is Rutao Cui, MD, PhD, of Dana-Farber and Children’s Hospital. Co-authors include Hans Widlund, PhD, Erez Feige, PhD, Jennifer Lin, MD, Dara Wilensky, Vivien Igras, and John D’Orazio, MD, PhD, formerly of Dana-Farber and Children’s and now at the University of Kentucky College of Medicine; Scott Granter, MD, of Dana-Farber and Brigham and Women’s Hospital; Claire Fung, MD, of Massachusetts General Hospital; and Carl Schanbacher, MD, of Brigham and Women’s.

The research was supported by a grant from the National Institutes of Health, and the Doris Duke Charitable Foundation.

 
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